Which integumentary changes are typically observed in patients with chronic CKD?

Brittle nails are a common integumentary change observed in patients with chronic chronic kidney disease (CKD). This condition affects the body's ability to process and eliminate toxins, leading to various systemic effects, including those on the skin and appendages such as hair and nails. The deterioration of the structural proteins within the nails can lead to brittleness, making them more susceptible to breaking or splitting.

Chronic kidney disease can also affect the body's hydration levels and nutrient absorption, which may further contribute to changes in nail health. The skin as a whole might exhibit alterations due to hormonal and metabolic imbalances related to kidney function, but brittle nails specifically highlight the impact CKD can have on keratin production and overall nail integrity. Understanding the relationship between CKD and such dermatological manifestations is important for managing patient care effectively, and acknowledging these changes can aid in timely interventions to improve quality of life for affected individuals.